Cardiolipin Antibodies, IgG, IgM, and IgA
Also known as: CARD PAN
Use
The test measures the presence of cardiolipin antibodies (IgG, IgM, IgA) which can be indicative of antiphospholipid syndrome (APS). Persistent moderate or high levels of these antibodies are a laboratory criterion for the diagnosis of APS. The presence of these antibodies may also occur in patients with clinical symptoms of APS, although their significance in lower positive levels remains undefined. Accurate diagnosis requires correlation with APS-specific clinical manifestations and other phospholipid antibody tests.
Special Instructions
This test is not recommended as a panel for diagnosing antiphospholipid syndrome (APS). Instead, the Cardiolipin Antibodies, IgG and IgM (0099344) test is preferred. Serum should be separated from cells as soon as possible or within two hours of collection and transferred to an ARUP Standard Transport Tube.
Limitations
The test should not be used alone for APS diagnosis due to the undefined significance of moderate to low antibody levels. Antibody presence needs confirmation through consistent results in specimens drawn at least 12 weeks apart. The test does not replace APS-specific criteria tests and should be used in conjunction with clinical evaluation.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 3181-5
- 3182-3
- 5076-5
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect in a serum separator tube and separate serum from cells ASAP or within 2 hours of collection. Transfer to transport tube.
Causes for Rejection
Plasma or other body fluids. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |