Chorionic Villus, FISH
Also known as: FISHCVS
Use
The test is used for rapid detection of aneuploidy involving chromosomes X, Y, 13, 18, and 21. It provides critical prenatal information, especially in cases where there is an increased risk of chromosomal abnormalities due to factors such as abnormal cell-free DNA results or increased nuchal translucency. Since it targets common aneuploidies, the information it provides can assist in making important clinical decisions about pregnancy management.
Special Instructions
Not provided.
Limitations
This FISH analysis does not rule out aneuploidy of chromosomes other than 13, 18, 21, X, and Y. It will not detect structural abnormalities or mosaicism and cannot provide structural information for detected gains. Interphase FISH analysis assumes that fetal chromosome complements are represented accurately by extra-embryonic tissue, which may not always be the case. Maternal cell contamination can also interfere with results.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number Region
LOINC Codes
- 55193-7 - Chrom analy interphase CVS FISH-Imp
- 11526-1 - Pathology study
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (Unknown)
Volume
Not provided
Minimum Volume
Not provided
Container
Sterile, screw-top container filled with tissue culture transport medium
Collection Instructions
Thaw media prior to collection. Transport in a sterile, screw-top container filled with tissue culture transport medium.
Storage Instructions
Transport at room temperature.
Causes for Rejection
Frozen specimens. Specimens preserved in formalin.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant