Chromosome Analysis, Chorionic Villus with Reflex to ClariSure®, Oligo‑SNP, Prenatal
Also known as: SNP array, ClariSure®, CVS, Karyotype, Prenatal
Use
Testing determines chromosomal status of the fetus. Numerical and structural chromosomal abnormalities can be diagnosed. Sex and the presence of more than one cell line (mosaicism) can also be determined. Indications include diagnosis of chromosome abnormalities in fetuses of women who are of advanced maternal age; had a previous child with a chromosome abnormality; parental carrier of a balanced translocation, inversion or marker chromosome; parental mosaicism. Chromosomal microarray (ClariSure® Oligo‑SNP) may be performed for further investigation of abnormal ultrasound findings, further definition of imbalanced cytogenetic abnormalities, investigation of equivocal cytogenetic findings, characterization of supernumerary marker chromosomes, follow‑up to familial genomic alterations, or family history of phenotypic abnormalities. (Derived from listing and additional context.)
Special Instructions
Physician attestation of informed consent is required when ordering from specific states. Signed informed consent is required. Complete cytogenetics requisition form with patient age, gestational age, and indication(s) is necessary. CVS transport media and handling instructions are available upon request. Specimen viability decreases during transit. This is a reflex test: if chromosome analysis is normal, then the ClariSure® Oligo‑SNP microarray will be performed at additional charge.
Limitations
Not provided.
Methodology
Cell-based / Cytometry
Biomarkers
Result Turnaround Time
6-8 days
Related Documents
For more information, please review the documents below
Specimen
Tissue
Volume
40 mg
Minimum Volume
20 mg
Container
CVS transport media
Collection Instructions
Collect chorionic villus sampling in CVS transport media; do not split; send all tubes to lab; media and handling instructions available upon request.
Patient Preparation
Physician attestation of informed consent required in certain states.
Causes for Rejection
Specimen viability decreases during transit.
