Circulating Immune Complex Panel
Also known as: CIC-C3,C1Q
Use
The Circulating Immune Complex Panel is used to detect circulating immune complexes, which are associated with various autoimmune disorders, chronic infections, and malignancies. Quantitation of these complexes aids in staging immunologic disorders, though detection is not essential for specific diagnoses. Positive results do not automatically indicate an immune complex-related disease, as these complexes can be present without evident pathology.
Special Instructions
Ensure serum is separated from cells within 30 minutes and frozen immediately after clotting. Two aliquots of 1 mL each are required, preferably transported in ARUP Standard Transport Tubes.
Limitations
Circulating immune complexes may be found without any evident pathology, and therefore, positive results do not necessarily implicate an immune complex in a disease process. Values for Circulating Immune Complex, C3 fragments between 15 and 20 µg Eq/mL are considered equivocal, warranting repeat testing if clinically indicated.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 27831-7
- 5228-2
Result Turnaround Time
2-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 x 1 mL aliquots
Minimum Volume
0.5 mL/aliquot
Container
ARUP Standard Transport Tubes
Collection Instructions
Allow complete clotting of red blood cells up to 1 hour, then separate serum from cells within 30 minutes. Freeze immediately.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted for multiple tests.
Causes for Rejection
Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles. Grossly hemolyzed, lipemic, and icteric specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | 2 weeks |