Coxiella burnetii (Q-Fever) Antibodies, IgG and IgM, Phase I and II with Reflex to Titer
Also known as: Q-F GM
Use
This test is used to confirm the presence of the infectious agent Coxiella burnetii (Q-fever) in symptomatic patients. Detection of IgG and IgM antibodies to phase I and phase II antigens assists in diagnosing both acute and chronic Q fever infections. Acute infection typically shows a four-fold rise in phase II IgG titers, and chronic infection is indicated by a phase I titer greater than the phase II. Additional serological testing may be required to confirm diagnosis, and the phase II IgM titers can aid in diagnosing early conversion in acute cases.
Special Instructions
Not provided.
Limitations
Limitations of the test include the potential for persistent elevation of IgG and IgM titers for months or years following acute infection or during convalescence. A single phase II IgM positive result on an acute sample may indicate early conversion or a false positive, requiring testing of a convalescent serum for confirmation. In chronic Q fever, absence of phase I IgG titer limits diagnostic value of phase I IgM titer.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Coxiella burnetii
Microorganism
LOINC Codes
- 48720-7 - C burnet Ph1 IgG Ser Ql IF
- 48719-9 - C burnet Ph2 IgG Ser Ql IF
- 63455-0 - C burnet Ph1 IgM Ser Ql IF
- 43928-1 - C burnet Ph2 IgM Ser Ql IF
Result Turnaround Time
1-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |
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