Cytokeratin 5,6 (CK 5,6) by Immunohistochemistry
Also known as: CYTO56 IHC
Use
Cytokeratin 5,6 analysis by immunohistochemistry is useful for identifying and differentiating certain subtypes of epithelial tumors. The presence of these cytokeratins can be indicative of specific tumor origins, helping in histopathological diagnosis and management decisions for cancer patients.
Special Instructions
This test is performed as a stain and return (technical) service only. Submit an electronic request or use ARUP Immunohistochemistry Stain Form (#32978) if electronic ordering is unavailable. Include the ARUP client number. Use ARUP supply #47808 for tissue transport.
Limitations
The test is limited to stained slide analysis and does not provide a quantitative assessment of cytokeratin 5,6 expression levels. It requires formalin-fixed and paraffin-embedded tissue or cell block specimens, as the methodology cannot be applied to fresh, frozen, or inadequately preserved samples. Excessive heat exposure during storage or transport may compromise specimen integrity.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 94736-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue transport kit (ARUP supply #47808)
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides.
Storage Instructions
Protect paraffin block and/or slides from excessive heat. Transport at room temperature or refrigerated.
Causes for Rejection
Specimens submitted with non-representative tissue type. Depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |