Growth Hormone, 0 Minutes
Also known as: GH 0
Use
The Growth Hormone, 0 Minutes test is used to evaluate growth hormone deficiency (GHD) or excess in patients. In pediatric patients, very low peak growth hormone concentrations on stimulation tests suggest severe GHD, although thresholds for partial GHD aren't well defined. In adults, expected GH peaks depend on the stimulation test used, following Endocrine Society guidelines. For suppression tests, healthy subjects typically have GH concentrations below 1 ng/mL within 2 hours post-glucose ingestion, while patients with acromegaly may not display normal suppression.
Special Instructions
This Growth Hormone assay is standardized to the Recombinant Second International Standard (IS): 98/574, resulting in approximately 25% lower readings compared to previous standards. Reference ranges are adjusted per the assay manufacturer.
Limitations
Thresholds distinguishing normal from partial GHD have not been well established, requiring inadequate responses to two different provocative tests for GHD diagnosis. This test may not distinguish between different systemic or localized endocrine issues nor between causes of abnormal growth hormone levels without additional context.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Chemiluminescent)
Biomarkers
LOINC Codes
- 12253-1
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.4 mL
Container
ARUP Standard Transport Tubes
Collection Instructions
Allow specimen to clot completely at room temperature. Separate serum or plasma from cells as soon as possible or within 2 hours of collection.
Causes for Rejection
Tissue or urine. Grossly hemolyzed or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 2 months |