Use

For pediatric patients, very low peak growth hormone concentrations on stimulation testing are consistent with severe growth hormone deficiency (GHD). Thresholds distinguishing normal from partial GHD have not been well established, and an inadequate response to two different provocative tests is required for the diagnosis of GHD. In adults, expected peak growth hormone concentrations depend on the stimulation test performed, as described in Endocrine Society guidelines for the evaluation and treatment of adults with GHD. For suppression testing, healthy subjects have growth hormone concentrations of less than 1 ng/mL within two hours of ingestion of a 75 or 100 gram glucose dose, while patients with acromegaly fail to show normal suppression.