Growth Hormone, 90 Minutes
Also known as: GH 90
Use
For pediatric patients, very low peak growth hormone (GH) concentrations on stimulation testing are consistent with severe GH deficiency (GHD). Thresholds distinguishing normal from partial GHD have not been well established. Inadequate response to two different provocative tests is required for diagnosis of GHD. In adults, expected peak GH concentrations depend on the stimulation test performed, as described in Endocrine Society guidelines for the evaluation and treatment of adults with GHD. For suppression testing, healthy subjects have GH concentrations of less than 1 ng/mL within 2 hours of ingestion of a 75 or 100 gram glucose dose. Patients with acromegaly fail to show normal suppression.
Special Instructions
This Growth Hormone assay is standardized to the Recombinant Second International Standard (IS): 98/574. Growth hormone results read approximately 25 percent lower than with the previous standards (First IS: 80/505). Reference ranges have also been modified according to the assay manufacturer.
Limitations
Thresholds distinguishing normal from partial Growth Hormone Deficiency (GHD) have not been well established. The assay shows approximately 25 percent lower readings compared to previous standards, which may affect the interpretation of results based on historical reference ranges. It is important to use adequate calibration and controls based on the current standardization.
New York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 14147-3
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
0.4 mL
Container
Plasma separator tube or serum separator tube
Collection Instructions
Collect one tube per timed specimen. Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer to individual ARUP Standard Transport Tubes.
Storage Instructions
Frozen. Also acceptable: Refrigerated.
Causes for Rejection
Tissue or urine. Grossly hemolyzed or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 2 months |