H3.3 G34W Mutant by Immunohistochemistry

Also known as: H3G34W IHC

Clinical Use

Use

The H3.3 G34W Mutant by Immunohistochemistry test is designed to detect the presence of the H3.3 G34W mutation, which is associated with certain types of tumors. This mutation occurs in the histone H3.3 protein and is considered a biomarker for specific tumor types. Identification of this mutation may aid in the diagnosis and classification of these tumors, providing valuable information for clinical decision-making and patient management.

Special Instructions

Not provided.

Limitations

This test is performed as a technical service only, meaning that it serves as a stain and return service. The test has been developed and performance characteristics determined by ARUP Laboratories, but it has not been cleared or approved by the FDA. As such, results should be interpreted by a qualified healthcare professional within the broader context of the patient's clinical situation.

Test Details

New York Approved

Methodology

Immunoassay (IHC)

Biomarkers

H3.3 G34W

Protein

IHC

Expression • Categorical (e.g., Positive / Negative / Indeterminate)

Result Turnaround Time

1-3 days

Specimen

Tissue (FFPE)

Volume

Not provided

Minimum Volume

2 slides

Container

Tissue Transport Kit

Collection Instructions

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides.