Insulin-Like Growth Factor 1 (IGF-1) with Calculated Z-Score
Also known as: IGF-1Z
Use
The test aids in the diagnosis of growth hormone excess or deficiency disorders, such as Acromegaly and Growth Hormone Deficiency. It measures the level of IGF-1 which is an indicator of growth hormone activity in the body. A calculated Z-Score helps in assessing the age- and sex-adjusted IGF-1 level by comparing it to the population mean. This evaluation is crucial for managing and diagnosing conditions associated with abnormal growth hormone levels.
Special Instructions
Not provided.
Limitations
Plasma, tissue, or urine specimens are unsuitable for this test, as are grossly hemolyzed or lipemic specimens. The test does not establish IGF-1 reference intervals for individuals older than 85 years, which may limit its applicability in diagnosing growth hormone disorders in this age bracket. Z-scores outside the -2.0 to 2.0 range may require further clinical correlation and investigation to understand the root cause, as these scores are indicative and not definitive diagnostics.
New York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 2484-4 - IGF-I SerPl-mCnc
- 73561-3 - IGF-I Z-score SerPl
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect in Serum Separator Tube (SST).
Storage Instructions
Transport frozen. After separation, Ambient stability is 24 hours, refrigerated is 1 week, and frozen is 1 year.
Causes for Rejection
Plasma, tissue, or urine specimens. Grossly hemolyzed or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 1 year |
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