Islet Antigen-2 (IA-2) Autoantibody, Serum

Casandra

Casandra Test Code AR54128Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3001499CPT Code 86341

Islet Antigen-2 (IA-2) Autoantibody, Serum

Also known as: IA-2 AB

Clinical Use

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Use

This assay is intended for the quantitative determination of autoantibodies to Islet Antigen-2 (IA-2) in human serum. It is used to establish an autoimmune etiology in patients with previously diagnosed type 1 diabetes mellitus (DM). A value greater than or equal to 7.5 Units/mL is considered positive for IA-2 autoantibodies. The test is most useful for identifying autoimmune diabetes mellitus and should be considered in cases where autoimmune diabetes is suspected, especially when differentiating from other types of diabetes mellitus.

Special Instructions

For testing autoimmune diabetes mellitus, it is advised to perform at least two antibody tests. In most cases, this should include the glutamic acid decarboxylase antibody test in combination with another antibody test, such as IA-2. The test should not be used to differentiate type 1 DM from type 2 DM in most cases. Patient preparation involves collecting a serum specimen.

Limitations

The test is not designed to differentiate type 1 DM from type 2 DM in most instances. It should not be relied upon in isolation and should be interpreted within the context of clinical symptoms and other diagnostic tests. Unacceptable specimens include plasma, specimens in frozen SST, and grossly hemolyzed, icteric, or lipemic specimens. Results may be affected by improper specimen handling or preparation methods.

Test Details

FDA Approved