Maternal Screening, Sequential, Specimen #2, Alpha Fetoprotein, hCG, Estriol, and Inhibin A
Also known as: MS SEQ2
Use
This second-trimester screening test is used to assess the risk of fetal conditions such as trisomy 21 (Down syndrome), trisomy 18, and open neural tube defects. The test requires a previously submitted first-trimester specimen and nuchal translucency measurement carried out by a certified ultrasonographer. The risk assessment combines results from both the first and second trimesters, providing an integrated risk perspective for the conditions mentioned.
Special Instructions
Not provided.
Limitations
This screening test does not provide a definitive diagnosis for fetal conditions. Rather, it assesses the probability of certain aneuploidy and neural tube defects based on maternal serum markers and nuchal translucency measurements. False positives and negatives are possible, and further diagnostic testing may be required. Factors such as maternal age, weight, ethnicity, and diabetic status are considered in the risk calculation, but inaccuracies in these parameters or gestational age may affect results.
New York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 1834-1 - AFP SerPl-mCnc
- 35738-4 - Inhibin A MoM SerPl
- 23883-2 - Inhibin A SerPl-mCnc
- 20450-3 - AFP MoM SerPl
- 49586-1 - Integrated scn Patient-Imp
- 19151-0 - Specimen drawn SerPl
- 44877-9 - IDDM Patient Ql
- 8670-2 - Family member diseases Hx
- 21484-1 - Mother's race
- 11878-6 - # Fetuses US
- 21612-7 - Age - Reported
- 2250-9 - u Estriol SerPl-mCnc
- 20466-9 - u Estriol MoM SerPl
- 12146-7 - Fet Nuchal fold Thickness US.meas
- 32123-2 - PAPP-A MoM SerPl
- 49089-6 - Sonographer
- 49088-8 - Sonographer name
- 34970-4 - US Date
- 49035-9 - Fet Nuchal fold MoM Thickness US.meas
- 32435-0 - Hx of Hereditary disorders
- 48407-1 - PAPP-A SerPl-mCnc
- 64234-8 - Current smoker
- 11957-8 - Fet CRL US.meas
- 11526-1 - Pathology study
- 19080-1 - HCG SerPl-aCnc
- 20465-1 - HCG MoM SerPl
- 29463-7 - Weight
- 18185-9 - GA
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Serum separator tube (SST) or plain red
Collection Instructions
Specimen must be drawn between 14 weeks and 24 weeks 6 days of gestation. Recommended collection time is 16 to 18 weeks.
Storage Instructions
Refrigerated
Causes for Rejection
Plasma; Hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |
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