Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum
Also known as: NRNL IB S
Use
This test evaluates the presence of antineuronal antibodies (IgG) specifically targeting Hu, Ri, Yo, and Tr/DNER antigens. The detection of these antibodies aids in distinguishing classic paraneoplastic neurological disorders from other inflammatory neurological conditions. Anti-Hu is typically associated with small-cell lung cancer, Anti-Ri with neuroblastoma and certain adult malignancies, Anti-Yo with ovarian and breast cancer, and Anti-Tr with Hodgkin lymphoma. The concurrent presence of these antibodies indicates a potential paraneoplastic neurologic syndrome and warrants a targeted search for associated neoplasms.
Special Instructions
Not provided.
Limitations
Antineuronal antibodies detected by IB but not corroborated by IFA are of uncertain significance and should be clinically correlated with other findings. The test has limitations in diagnosing cases where novel or less common antineuronal antibodies might be involved, and is not yet FDA-approved for clinical use. Interpretation should be cautious when IFA results contradict IB findings, necessitating clinical context to affirm conclusions.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 12853-8 - Purkinje Cells Ab Ser Ql IB
- 63440-2 - PCA-Tr Ab Ser Ql IB
- 33008-4 - Hu2 Ab Ser Ql IB
- 41769-1 - Hu1 Ab Ser Ql IB
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.30 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer to transport tube.
Storage Instructions
Refrigerate after separation from cells.
Causes for Rejection
Plasma, contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |
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