Serine Proteinase 3 (PR3) Antibody

Also known as: PR3

Clinical Use

Use

The Serine Proteinase 3 (PR3) Antibody test is used, in conjunction with other autoantibody tests (such as ANCA and MPO), to aid in differentiating suspected Wegener granulomatosis from other vasculitides. It may also be useful for monitoring patients who have PR3 antibodies. Approximately 85% of patients with a C-ANCA pattern by IFA possess antibodies specific for PR3.

Special Instructions

Not provided.

Limitations

Plasma, urine, or other body fluids are considered unacceptable conditions for this test. Contaminated, hemolyzed, or severely lipemic specimens are also reasons for rejection. It is essential to avoid repeated freeze/thaw cycles to maintain specimen integrity.

Test Details

FDA Approved

New York Approved

Methodology

Immunoassay (Multiplex Protein Panel)

Biomarkers

Serine Proteinase 3

Protein

IgG

Expression • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Order Codes

6968-2 - Proteinase3 Ab Ser-aCnc

Result Turnaround Time

1-2 days

Specimen

Serum

Volume

1 mL

Minimum Volume

0.2 mL

Container

ARUP Standard Transport Tube

Collection Instructions

Collect serum in a serum separator tube. Separate serum from cells ASAP or within 2 hours of collection.

Storage Instructions

Store and transport serum refrigerated.

Causes for Rejection

Unacceptable conditions include plasma, urine, or other body fluids; contaminated, hemolyzed, or severely lipemic specimens; avoid repeated freeze/thaw cycles.