Anti-PR-3 Ab (RDL)
Also known as: Anti-Proteinase 3 Ab, PR-3 Ab, PR3
Use
PR-3 are an aid in the assessment of certain autoimmune vasculitides such as microscopic polyarteritis and crescentic glomerulonephritis. PR-3 is the major target antigen of antineutrophil cytoplasmic autoantibodies (ANCA) that give a cytoplasmic (C-ANCA) immunofluorescence pattern. Elevated levels of PR-3 autoantibodies are classically observed in patients with Wegener granulomatosis (WG), particularly with active disease, and less frequently in other forms of necrotizing vasculitis.
Special Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Limitations
The test is not specific for any particular disease and should be used in conjunction with clinical evaluation and other diagnostic tests. The presence of PR-3 autoantibodies might not correlate with active disease in all cases. Potential interference can be caused by hemolyzed, lipemic, or icteric samples as well as gross bacterial contamination.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 46267-1
- 46267-1
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |