MPO/PR3 (ANCA) Antibodies
Also known as: MPO/PR3
Use
The MPO/PR3 (ANCA) Antibodies test is used to monitor previously established MPO/PR3 antibodies or confirm an IFA ANCA positive test result. It's crucial for assessing patients with a history of vasculitis and helps in the workup of suspected vasculitis. Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO, while 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.
Special Instructions
Not provided.
Limitations
The test excludes ANCA testing by IFA, which can be critical in comprehensive diagnostics for vasculitis. The results are specific to MPO and PR3 antibodies and don't account for other possible antibodies that may be involved in similar clinical presentations. Results can be impacted by specimen conditions such as contamination, hemolysis, or severe lipemia.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
Myeloperoxidase (MPO)
ProteinSerine Proteinase 3 (PR3)
Protein
LOINC Codes
- 6968-2 - Proteinase3 Ab Ser-aCnc
- 6969-0 - Myeloperoxidase Ab Ser-aCnc
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to the transport tube.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma, urine, or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |
Other tests from different labs that may be relevant