MPO/PR3 (ANCA) Antibodies
Also known as: MPO/PR3
Use
The MPO/PR3 (ANCA) Antibodies test is used to monitor previously established MPO/PR3 antibodies or confirm an IFA ANCA positive test result. It's crucial for assessing patients with a history of vasculitis and helps in the workup of suspected vasculitis. Approximately 90% of patients with a P-ANCA pattern by IFA have antibodies specific for MPO, while 85% of patients with a C-ANCA pattern by IFA have antibodies specific for PR3.
Special Instructions
This test does not include ANCA testing by IFA. Patients with suspected vasculitis or a positive IFA ANCA result should consider further testing using the ANCA-Associated Vasculitis Profile (ANCA/MPO/PR3) or other related tests as mentioned for comprehensive analysis.
Limitations
The test excludes ANCA testing by IFA, which can be critical in comprehensive diagnostics for vasculitis. The results are specific to MPO and PR3 antibodies and don't account for other possible antibodies that may be involved in similar clinical presentations. Results can be impacted by specimen conditions such as contamination, hemolysis, or severe lipemia.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 6968-2
- 6969-0
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to the transport tube.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma, urine, or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |