11-Deoxycortisol, Two Specimens
Also known as: 11-Desoxycortisol
Use
Used to assess adrenal gland function by measuring 11‑deoxycortisol levels at two time points (baseline and post‑metyrapone), e.g., as part of metyrapone testing or ACTH stimulation, to evaluate cortisol biosynthesis and hypothalamic‑pituitary‑adrenal axis reserve. 11‑deoxycortisol is the immediate precursor of cortisol and increases after metyrapone administration, aiding in diagnosis of congenital adrenal hyperplasia and enzyme deficiencies.
Special Instructions
Submit two tubes: one labeled “baseline” and one labeled “post‑metyrapone.” Each specimen must be frozen immediately and maintained frozen until tested; specimens should be submitted separately if multiple tests are ordered on frozen samples.
Limitations
Not provided.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 40810-4
- 41289-0
Result Turnaround Time
6-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL (each specimen)
Minimum Volume
0.2 mL (each specimen)
Container
Red‑top tube, gel‑barrier tube, lavender‑top (EDTA) tube, or green‑top (heparin) tube
Collection Instructions
Transfer serum (or plasma) and freeze immediately; separate frozen specimens per test to avoid delays; label one as baseline and one as post‑metyrapone.
Storage Instructions
Freeze.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 day |
| Refrigerated | 1 day |
| Frozen | 2 years |