Aldolase
Use
Evaluate muscle wasting process. High levels are found in progressive Duchenne muscular dystrophy (MD). Elevations occur in carriers of MD, in limb-girdle dystrophy and other dystrophies, in dermatomyositis, polymyositis, and trichinosis, but not in neurogenic atrophies (eg, multiple sclerosis or in myasthenia gravis).
Special Instructions
Not provided.
Limitations
Serum aldolase elevation is not specific for muscle disease as it is present in various tissues. In progressive dystrophies, elevated levels may decline with muscle wasting. The enzymatic method determines total enzyme activity without being specific for muscle aldolase. Elevated aldolase levels may also be found with various conditions such as hepatitis, liver diseases, myocardial infarction, and others.
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
Aldolase
Analyte
LOINC Codes
- 1761-6 - Aldolase SerPl-cCnc
- 1761-6 - Aldolase SerPl-cCnc
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
Red-top tube or gel-barrier tube for serum
Collection Instructions
Separate serum or plasma immediately after coagulation (30 minutes).
Storage Instructions
Refrigerate.
Causes for Rejection
Hemolysis (red cells contain aldolase); gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 day |
| Refrigerated | 7 days |
| Frozen | 15 days |
Other tests from different labs that may be relevant