Aldosterone, LC/MS, Two Specimens
Use
This test is intended for the measurement of aldosterone levels in two separate specimen samples collected from a patient. Aldosterone is a hormone produced by the adrenal glands that helps regulate blood pressure by controlling sodium and potassium levels in the blood. This test can aid in the diagnosis of conditions such as hyperaldosteronism and help in monitoring aldosterone production in patients undergoing treatment. The use of LC/MS (liquid chromatography-mass spectrometry) ensures high sensitivity and specificity for the aldosterone measurement.
Special Instructions
This is a series panel requiring multiple tubes to be drawn at different times. Initial tube is collected (baseline), followed by a treatment (e.g., medication or glucose ingestion), then subsequent tubes are collected post-treatment. The series should not commence without clinician consultation to confirm the order.
Limitations
This test requires multiple specimens collected at different times, so it may not be suitable for patients unable to comply with this collection schedule. The test has not been cleared or approved by the FDA, which may limit its clinical validity and utility. Potential pre-analytical issues such as improper specimen handling or timing could affect the test results. Cross-reactivity and specificity limitations inherent to mass spectrometry technology may also exist.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 27988-5
- 27988-5
- 46963-5
- 43604-8
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
2 mL
Container
Two serum separator tubes (SST) collected at different times.
Collection Instructions
Collect two specimens: the initial and another post-treatment (e.g., pill, shot, or glucola) sample. Ensure time-point accuracy to ensure reliable results.
Patient Preparation
Patient should follow standard endocrine test preparation guidelines; fasting overnight is recommended.
Storage Instructions
Refrigerate immediately after collection and freeze before transport.
Causes for Rejection
Hemolysis, improper labeling, incorrect tube type.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 hours |
| Refrigerated | 8 hours |
| Frozen | 30 days |