Anti-Scl-70 Ab (RDL)
Also known as: SCLER 70, topoisomerase 1
Use
The presence of anti-Scl-70 antibodies supports the diagnosis of scleroderma but does not exclude additional diagnosis, e.g., scleroderma and SLE or scleroderma and Sjogren's syndrome. Anti-Scl-70 antibodies are present in 20% of scleroderma patients irrespective of age and in the same percentage of males and females. In American patients with proximal scleroderma, anti-Scl-70 Abs are more common in African Americans than in Caucasians.
Special Instructions
Not provided.
Limitations
The detection of antibodies does not exclude other associated autoimmune conditions. A negative result does not rule out scleroderma, as anti-Scl-70 antibodies are not present in all cases. Further confirmatory tests might be required for a conclusive diagnosis.
Methodology
Immunoassay (ELISA)
Biomarkers
Anti-Scl-70 (Topoisomerase I)
Protein
LOINC Codes
- 5348-8 - ENA Scl70 Ab Ser Ql IA
- 5348-8 - ENA Scl70 Ab Ser Ql IA
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |
Other tests from different labs that may be relevant