Anti-Synthetase Profile (RDL)
Use
This Anti-Synthetase Profile is comprised of Anti-Jo-1 Ab, Anti-PL-7 Ab, Anti-PL-12 Ab, Anti-EJ Ab and Anti-OJ Ab. Anti-synthetase syndrome is an autoimmune disease characterized by interstitial lung disease (ILD), non-erosive arthritis, myositis, Raynaud’s phenomenon, unexplained fever and/or mechanic’s hands.1
Special Instructions
The test includes antibodies such as Anti-EJ Ab, Anti-Jo-1 Ab, Anti-OJ Ab, Anti-PL-7 Ab, and Anti-PL-12 Ab. Specimen handling requires serum to be separated from cells within one hour of collection and transferred to a plastic transport tube. If multiple tests are requested on frozen samples, separate frozen specimens should be submitted for each test to avoid delays.
Limitations
This test has been developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration. Test results should be interpreted alongside clinical findings and other laboratory tests due to overlapping phenotypes of antibodies associated with anti-synthetase syndrome.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 97564-9
- 35333-4
- 33772-5
- 33771-7
- 45149-2
- 45152-6
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. Submit separate frozen specimens for each test if requesting multiple tests on frozen samples.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |