Jo-1 Antibody, IgG
Also known as: ANTI-JO
Use
The presence of Jo-1 (antihistidyl transfer RNA [t-RNA] synthetase) antibody is associated with the clinical diagnosis of polymyositis and other related inflammatory myopathies. This antibody can also be found in patients with dermatomyositis, interstitial lung disease, Raynaud phenomenon, arthritis, and antisynthetase syndrome. The presence of the antibody may indicate pulmonary involvement as well as the characteristic 'mechanic's hands.'
Special Instructions
Recommended as the first-line test for the evaluation of polymyositis or inflammatory myopathies. Specimens should be handled with proper timing; serum must be separated from cells ASAP or within 2 hours of collection, and then transferred to a proper transport tube as per guidelines.
Limitations
The test may not detect all cases of polymyositis or related conditions as antibodies may not be present in all patients with these diagnoses. False positives or negatives are possible, and additional clinical evaluation and testing may be necessary to confirm or refute the presence of a Jo-1 antibody. Variability in the presence of the antibody across different patient populations or stages of disease may also affect results.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 33571-1
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer to transport tube.
Storage Instructions
Refrigerated
Causes for Rejection
Plasma or other body fluids.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |