Anti-Jo-1 Ab (RDL)
Also known as: Histidyl tRNA synthetase, Jo 1
Use
Jo-1 antibodies are found in approximately 20% of adult patients with myositis (including polymyositis, dermatomyositis and overlap syndromes) and particularly common (about 60%) in patients with both myositis and interstitial lung disease (cryptogenic fibrosing aveolitis or pulmonary interstitial fibrosis).
Special Instructions
This test is a component of several profiles including Myomarker 3 Profile, Myomarker 3 Plus Profile, Interstitial Lung Disease Panel I, Interstitial Lung Disease Panel II, ILDx Complete, and Anti-Synthetase Profile.
Limitations
The test's limitations are not explicitly mentioned, but it typically pertains to its specificity in detection of the Jo-1 antibodies, which may not detect antibodies present below the assay's sensitivity limit. Cross-reactivity with other autoantibodies or biological noise in certain patient populations may also affect result interpretation.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 11565-9
- 11565-9
Result Turnaround Time
5-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 60 days |