ASH FibroSure®
Also known as: Alcoholic Liver Disease, Noninvasive Liver Biopsy, Steatohepatitis
Use
This test is intended for noninvasive assessment of liver status in patients with alcoholic liver disease. Quantitative results of 10 biochemicals in combination with age, gender, height, and weight are analyzed using a computational algorithm to provide a quantitative surrogate marker (0.0-1.0) of liver fibrosis (Metavir F0-F4), hepatic steatosis (0.0-1.0, S0-S3), and alcoholic steatohepatitis (ASH) (0.0-1.0, H0-H3).
Special Instructions
The patient's age, gender, height, and weight at the time of collection must be submitted for FibroSure® testing.
Limitations
ASH FibroSure® is recommended for patients with suspected alcoholic liver disease. It is not recommended for patients with other liver diseases. It is also not recommended in patients with Gilbert disease, acute hemolysis, acute hepatitis, acute inflammation of the liver, extrahepatic cholestasis, transplant patients, and/or renal insufficiency patients. Any of these clinical situations may lead to inaccurate quantitative predictions of fibrosis. If any markers are unusually high or low, the algorithm may not calculate scores accurately.
Methodology
Other
Biomarkers
LOINC Codes
- 48792-6
- 48793-4
- 62364-5
- 3137-7
- 3141-9
- 1835-8
- 4542-7
- 1869-7
- 1975-2
- 2324-2
- 1743-4
- 30239-8
- 2093-3
- 2345-7
- 2571-8
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3.5 mL
Minimum Volume
2 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within two hours of collection, and transfer serum to a transfer tube.
Patient Preparation
Patient should be fasting for at least eight hours.
Storage Instructions
Specimen can be stored refrigerated at 2°C to 8°C for 72 hours and frozen at -70°C for seven days. Frozen samples are stable for one freeze/thaw cycle.
Causes for Rejection
Gross hemolysis; gross lipemia; improper labeling; nonfasting specimen; patient younger than 14 years of age
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |
| Frozen | 7 days |