C-Telopeptide (Endocrine Sciences)
Also known as: Carboxyterminal Cross-linking Telopeptide of Bone Collagen, Collagen Cross-linked C-Telopeptide, Crosslaps, Type 1 Collagen
Use
For in vitro diagnostic use as an indicator of human bone resorption. This test may be used as an aid in monitoring bone resorption changes of antiresorptive therapies in postmenopausal women, individuals with osteopenia, and in predicting skeletal response (bone mineral density) in postmenopausal women undergoing antiresorptive therapies.
Special Instructions
This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin. It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
Limitations
This test is not intended to predict the development of osteoporosis or future fracture risk. The use of this test has not been established in hyperparathyroidism or hyperthyroidism. When using the test to monitor therapy, results may be confounded in patients afflicted with clinical conditions known to affect bone resorption. Results should be interpreted in conjunction with clinical findings and other diagnostic results and should not be used as a sole determination in initiating or changing therapy. Note: Serum values are not interchangeable with urine values.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 41171-0
- 41171-0
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Gel-barrier tube
Collection Instructions
It is recommended to draw blood as fasting, morning samples. Separate serum from cells within 45 minutes of collection. Transfer specimen to a plastic transport tube before freezing.
Patient Preparation
Samples should not be taken from patients receiving therapy with high biotin doses until at least 8 hours following the last biotin administration.
Storage Instructions
Freeze.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 day |
| Refrigerated | 14 days |
| Frozen | 2 years |