Chromosome Analysis, Tissue Biopsies (Products of Conception, Skin)

Also known as: Long-term Culture, Fibroblast Karyotype Study, Placental Tissue Chromosome Analysis, Spontaneous Abortion Chromosome Analysis, Tissue Karyotype

Clinical Use

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Use

Evaluate possible chromosomal abnormalities as the cause of miscarriage. Extended study of mosaicism found in blood chromosome analysis.

Special Instructions

Not provided.

Limitations

Some products of conception may only contain maternal tissue which might affect test accuracy. Additionally, subtle chromosomal rearrangements below the resolution of cytogenetic methods or congenital anomalies caused by non-chromosomal factors will not be detected by this test. Tissue viability could be compromised in conditions where fetal tissue is not viable; hence results must be carefully interpreted in the context of clinical findings and other diagnostic tests.

Test Details

Methodology

Chromosomal / Cytogenetics (Karyotype)

Biomarkers

Karyotype

Other

20 Metaphases; 2 to 3 Karyotypes

Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Order Codes

62386-8 - Chrom anl summary pnl

Result Codes

62361-1 - Cells counted
55199-4 - Cells karyotyped.total Bld/T
62360-3 - Cells analyzed
62358-7 - ISCN band level Ql
62356-1 - Chrom analy result (ISCN)
62357-9 - Chrom analy overall interp-Imp
48002-0 - Genomic source class
48672-0 - Clinical cytogeneticist Spec
11502-2 - Laboratory report

Result Turnaround Time

11-16 days

Specimen

Tissue (Unknown)

Volume

2 to 4 mm³

Minimum Volume

Not provided

Container

Submit biopsies in a sterile tube with sterile Ringer's lactate, Hanks' balanced salt solution or Labcorp transport medium.

Collection Instructions

Aseptically obtain a small piece of tissue with subepidermal layers. Best results are obtained from placental villi, which remain viable much longer than fetal tissue. Ensure aseptic collection to avoid contamination with maternal tissue.