Factor XIII
Also known as: Factor XIII, Qualitative, Fibrin Stabilizing Factor
Use
This is a screening assay and will detect homozygous deficiency of factor XIII.
Special Instructions
If the patient's hematocrit exceeds 55%, the citrate volume in the collection tube must be adjusted. Refer to Coagulation Collection Procedures for directions. Avoid warfarin therapy for two weeks and heparin therapy for two days prior to the test. Ensure proper blood-to-anticoagulant ratio by filling evacuated collection tubes completely and mixing immediately by gentle inversion.
Limitations
This is a screening assay only and will show abnormal results when factor XIII levels are less than 1% to 2%. It will not provide quantitative levels of FXIII activity. For a quantitative functional analysis of FXIII, further testing with a different method is recommended. The test is limited to severe deficiencies and may not detect moderate or mild deficiencies. Interpreting results requires considering potential interference from conditions such as disseminated intravascular coagulation or liver disease.
Methodology
Other
Biomarkers
LOINC Codes
- 3241-7
- 3241-7
Result Turnaround Time
3-4 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
Not provided
Container
Blue-top (sodium citrate) tube
Collection Instructions
Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood-to-anticoagulant ratio. Mix immediately by gentle inversion at least six times. If using a winged collection set, a discard tube should be drawn first to prevent under-filling.
Patient Preparation
Avoid warfarin (Coumadin®) therapy for two weeks and heparin therapy for two days prior to the test. Do not draw from an arm with a heparin lock or heparinized catheter.
Storage Instructions
Freeze.
Causes for Rejection
Gross hemolysis; clotted specimen; frozen specimen thawed in transit; improper labeling