HPA-1a (PLA1 Platelet Antigen) Genotyping (PLA2 Polymorphism Detection)
Also known as: PLA2 Polymorphism Detection
Use
Individuals negative for the HPA-1a (PLA1) antigen are at risk for developing antibodies to this antigen as may occur in neonatal alloimmune thrombocytopenia and post-transfusion purpura.
Special Instructions
Not provided.
Limitations
The mechanism of platelet destruction in post-transfusion purpura is poorly understood. This is a molecular test for genotyping and may not detect rarer mutations or polymorphisms outside the targeted locus.
Methodology
PCR-based (PCR)
Biomarkers
No genes
Gene
LOINC Codes
- 50599-0 - HPA-1 Bld
- 69049-5 - Coagulation specialist review
- 8251-1 - Service Cmnt-Imp
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
Blue-top (sodium citrate) tube, lavender-top (EDTA) tube, or yellow-top (ACD) tube
Storage Instructions
Maintain specimen at room temperature. Stable at room temperature or refrigerated for eight days.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 days |
| Refrigerated | 8 days |
Other tests from different labs that may be relevant