Killer Immunoglobulin-like Receptors (KIR)
Also known as: KIR, KIR Genotyping, KIR SSO Genotyping Test, KIR Typing
Use
The function of natural killer cells in the immune response is regulated by killer immunoglobulin-like receptors (KIR). These receptors interact with class I HLA antigens on the cell surface to prevent or activate killing of the target cell. KIR genotyping may be useful in some stem cell transplants because KIR matching or mismatching can mediate a graft-versus-leukemia effect when the cancer cells are underexpressing HLA class I antigens.
Special Instructions
Not provided.
Limitations
Results for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.
Methodology
Microarray
Biomarkers
LOINC Codes
- 64413-8 - KIR 2DL1 Bld/T Ql
- 64414-6 - KIR 2DL2 Bld/T Ql
- 64415-3 - KIR 2DL3 Bld/T Ql
- 64416-1 - KIR 2DL4 Bld/T Ql
- 64419-5 - KIR 2DL5 Bld/T Ql
- 64420-3 - KIR 2DS1 Bld/T Ql
- 64421-1 - KIR 2DS2 Bld/T Ql
- 64422-9 - KIR 2DS3 Bld/T Ql
- 64423-7 - KIR2DS4 full variant Bld/T Ql
- 64424-5 - KIR2DS4 del variant Bld/T Ql
- 64425-2 - KIR 2DS5 Bld/T Ql
- 64426-0 - KIR 3DL1 Bld/T Ql
- 64427-8 - KIR 3DL2 Bld/T Ql
- 64428-6 - KIR 3DL3 Bld/T Ql
- 64429-4 - KIR 3DS1 Bld/T Ql
- 64430-2 - KIR 2DP1 Bld/T Ql
- 64431-0 - KIR3DP1 full variant Bld/T Ql
- 49549-9 - Ref lab test method
Result Turnaround Time
3-9 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
7 mL
Minimum Volume
3 mL
Container
Lavender-top (EDTA) tube
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Highly lipemic or hemolyzed specimen
Other tests from different labs that may be relevant