Liver-Kidney Microsomal (LKM) Antibodies
Also known as: LKM, LKM-1 Antibodies
Use
The detection of LKM-1 antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH-2). LKM antibodies are markers of AIH-2 which usually begins in childhood and generally affects children younger than 18 years of age. LKM antibodies are associated with a more serious progression of the disease. The disease is most common between the ages of 2 to 14 and is more frequent in females than males (8:1). LKM-1 antibodies have been reported in up to 8% of patients with chronic HCV infection.
Special Instructions
Turnaround time refers to the typical number of days from specimen pickup to result release. Additional time may be required for confirmatory or reflex tests. Testing schedules can vary.
Limitations
A negative LKM-1 antibody result does not definitively exclude the presence of autoimmune hepatitis type 2. Furthermore, the presence of LKM-1 antibodies in some patients may be due to an HCV infection rather than indicating AIH-2. These factors necessitate a comprehensive clinical assessment.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 32220-6
- 32220-6
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |