Liver-Kidney Microsomal (LKM) Antibodies
Also known as: LKM, LKM-1 Antibodies
Use
The detection of LKM-1 antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH-2). LKM antibodies are markers of AIH-2 which usually begins in childhood and generally affects children younger than 18 years of age. LKM antibodies are associated with a more serious progression of the disease. The disease is most common between the ages of 2 to 14 and is more frequent in females than males (8:1). LKM-1 antibodies have been reported in up to 8% of patients with chronic HCV infection.
Special Instructions
Not provided.
Limitations
A negative LKM-1 antibody result does not definitively exclude the presence of autoimmune hepatitis type 2. Furthermore, the presence of LKM-1 antibodies in some patients may be due to an HCV infection rather than indicating AIH-2. These factors necessitate a comprehensive clinical assessment.
Methodology
Immunoassay (ELISA)
Biomarkers
Liver-Kidney Microsome Type 1 Antibodies
Protein
LOINC Codes
- 32220-6 - LKM-1 Ab Ser-aCnc
- 32220-6 - LKM-1 Ab Ser-aCnc
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; gross bacterial contamination; heat-treated specimen; specimen with preservative added
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant