Sjögren's Antibodies (Anti-SS-A/Anti-SS-B)
Also known as: Anti-La, Anti-Ro
Use
Aids in the diagnosis of Sjögren's syndrome (especially with vasculitis) and lupus patients with Sjögren's overlap syndrome.
Special Instructions
SS-A cannot be demonstrated by immunofluorescence due to its solubility in buffers used, but SS-B may be seen as a speckled antinuclear pattern.
Limitations
The test may have limitations in detecting SS-A by immunofluorescence techniques due to solubility issues. Also, there may be variability in the presence of antibodies with certain conditions like nephritis in ANA-positive individuals.
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 103139-2
- 17792-3
- 17791-5
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; icterus; lipemia; bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |