Thyroglobulin Antibody and Thyroglobulin, IMA or LC/MS-MS
Use
Thyroglobulin (Tg) measurement is intended to aid in monitoring for the presence of orthotropic and/or metastatic thyroid tissues in patients who have had thyroid gland ablation (using thyroid surgery with or without radioactivity). Measurement of thyroglobulin antibody (TgAb) is used to identify patient samples that may be affected by TgAb interference in the measurement of Tg. Quantitative TgAb concentrations can also serve as a surrogate tumor marker for DTC recurrence and for monitoring changes in tumor mass in certain patients.
Special Instructions
This test may exhibit interference when sample is collected from a person consuming a supplement with high doses of biotin. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
Limitations
Changes in serum Tg concentrations should be interpreted in light of the patient's clinical presentation, history, and additional testing. Single measurements near the detection limit are of limited value. Tg levels should be monitored over time, referencing postoperative baseline levels. Some thyroid tumors may not secrete detectable Tg or may secrete forms undetectable by some assays.
Methodology
Immunoassay (Other)
Biomarkers
LOINC Codes
- 8098-6
- 8098-6
- 3013-0
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL (two tubes, 1.5 mL each tube)
Minimum Volume
2 mL (two tubes, 1 mL each tube)
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells, and transfer specimen to a plastic transport tube.
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | 14 days |