Thyroid Peroxidase (TPO) Antibodies
Also known as: Antimicrosomal Antibody, Antithyroid Microsomal Antibody
Use
Differential diagnosis of hypothyroidism and thyroiditis
Special Instructions
This test may exhibit interference when the sample is collected from a person who is consuming a high dose of biotin supplements. Patients should stop biotin consumption at least 72 hours prior to specimen collection to avoid interference with the test results.
Limitations
The test should be used alongside an antithyroglobulin test, as autoimmune thyroiditis can involve responses to multiple antigens. Other autoimmune disorders and conditions like myxedema, granulomatous thyroiditis, nontoxic nodular goiter, and thyroid carcinoma may also produce thyroid antibodies. A small percentage of individuals without evidence of thyroid disease may test positive for antibodies, especially older females.
Methodology
Immunoassay (ECLIA)
Biomarkers
LOINC Codes
- 8099-4
- 8099-4
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.7 mL
Container
Red-top tube, gel-barrier tube
Collection Instructions
If a red-top tube or plasma is used, transfer separated serum or plasma to a plastic transport tube.
Patient Preparation
Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.
Storage Instructions
Room temperature
Causes for Rejection
Citrate plasma specimen; improper labeling
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |