VistaSeq® High/Moderate Risk Breast Cancer Panel
Also known as: Familial Cancer testing, Hereditary Cancer testing, Inherited Cancer testing
Use
This assay is intended for patients with a family history consistent with an inherited cancer syndrome.
Special Instructions
Not provided.
Limitations
Sequencing cannot detect variants in regions not covered by this analysis, including noncoding or deep intronic variants. The method may not reliably detect mosaic variants, inversions, or genomic rearrangements. Sequence analysis can be affected by allele drop-out due to rare variants, and does not allow conclusions regarding whether two heterozyous variants are present on the same or different chromosome copies. Copy number analyses may not detect genomic rearrangements such as translocations, inversions, or some partial exon rearrangements. The presence of pseudogenes can interfere with variant detection, and this test does not detect somatic variants. The presence of an inherited cancer syndrome due to a different genetic cause cannot be ruled out.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 73977-1 - Cancer multigene analysis Bld/T
- 31208-2 - Specimen source
- 51968-6 - Gene dis anl interp-Imp
- 69548-6 - Genetic var assess
- 47042-7 - Counseling note
- 48767-8 - Annotation comment Imp
- 49549-9 - Ref lab test method
- 75608-0 - Citation Ref Lab Test
- 72486-4 - Lab director name Provider
- 51969-4 - Gene analysis narr rpt Doc
Result Turnaround Time
20-28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
7 mL
Container
Lavender-top (EDTA) tube or yellow-top (ACD) tube
Collection Instructions
Blood is collected by routine phlebotomy.
Storage Instructions
Room temperature
Causes for Rejection
Frozen specimen; leaking tube; clotted specimen; grossly or hemolyzed specimen; quantity not sufficient for analysis; incorrect anticoagulant.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 60 days |
| Refrigerated | 60 days |
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