Coccidioides Antibody, Complement Fixation, CSF
Use
Infection by Coccidioides immitis can produce a spectrum of disease with most patients being asymptomatic and some developing disseminated disease including pneumonia and meningitis. C. immitis meningitis is associated with a mononuclear pleocytosis. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although some patients (~10%) may not have detectable antibody in CSF. False-negatives may occur in patients with solitary pulmonary lesions and cross‑reactions may occur in patients with active histoplasmosis. Elevated serum antibodies may be present in meningeal coccidioidomycosis.
Special Instructions
Not provided.
Limitations
False‑negatives may occur in patients with solitary pulmonary lesions. Patients with active histoplasmosis may generate cross reactions. Elevated serum antibodies may be present in patients with meningeal coccidiomycosis.
Methodology
Other
Biomarkers
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
1 mL
Minimum Volume
0.2 mL
Container
sterile plastic leak‑proof CSF container
Causes for Rejection
Gross hemolysis • Grossly icteric
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 30 days |
Other tests from different labs that may be relevant