Cyclosporine A, Trough, Immunoassay, Blood
Also known as: Sandimmune®
Use
Cyclosporine (Cyclosporin A) is an immunosuppressant therapeutic agent used in the prevention of organ graft rejection. Measurement of blood levels is recommended due to the inter‑individual variability of metabolism as well as the toxicity associated with excessive dosage. Therapeutic drug monitoring helps optimize dose and avoid toxicity, as high levels may lead to nephrotoxicity and low levels may risk organ rejection.
Special Instructions
Collect as a trough, 12 hours after last dose. Preferred specimen: lavender‑top (EDTA) tube; refrigerated transport. Patient preparation and collection timing are critical for accurate trough measurement.
Limitations
Not provided.
Methodology
Immunoassay (Other)
Biomarkers
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
2 mL (Min: 1 mL)
Minimum Volume
1 mL
Container
Lavender (EDTA) tube
Collection Instructions
Collect as a trough, 12 hours after last dose.
Storage Instructions
Refrigerated transport
Causes for Rejection
Clotted specimen.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 30 days |