Casandra
Casandra Test Code QD01514Version 1 (DRAFT)
Performing Lab
Purkinje Cell Cytoplasmic Antibody Type Tr (DNER), CBA IFA
Also known as: PCA-Tr
Clinical Use
Order TestUse
Delta/notch‑like epidermal growth factor‑related receptor (DNER) is a central nervous system‑specific ligand for the Notch receptors expressed by cerebellar Purkinje neurons, essential for the normal development of Purkinje cells and Bergmann glia. DNER is the target of PCA‑Tr antibodies associated with paraneoplastic cerebellar degeneration (PCD) in patients with Hodgkin’s lymphoma.
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
Methodology
Immunoassay (IHC)
Biomarkers
DNER
ProteinCBA IFA
Other • Binary (Detected / Not Detected)
Result Turnaround Time
8 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
red‑top tube (no gel)
Causes for Rejection
Serum separator tube (SST)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 21 days |
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