Anaplastic Lymphoma Kinase 1 (ALK-1) by Immunohistochemistry
Also known as: ALK1 IHC
Use
The Anaplastic Lymphoma Kinase 1 (ALK-1) by Immunohistochemistry test is intended for the clinical evaluation of tumors to determine the presence of the ALK protein expression. This test supports the diagnosis and characterization of certain malignancies, such as anaplastic large cell lymphoma, by detecting ALK protein overexpression or rearrangements, which can guide therapeutic decisions and interventions. ALK rearrangements are associated with a subset of cancers where targeted therapies may be effective.
Special Instructions
For ordering, submit an electronic request, or use an ARUP Immunohistochemistry Stain Form with an ARUP client number if electronic ordering is unavailable. The test is performed as a stain and return (technical) service. For additional technical details, contact ARUP Client Services at (800) 522-2787. Room temperature or refrigerated shipping is required during summer months to prevent specimen degradation.
Limitations
The test is performed as a stain-only service and does not include interpretive analysis. It is intended for technical purposes, and the performance characteristics were determined by ARUP Laboratories. It is not FDA-cleared or approved. The test is done in a CLIA-certified laboratory for clinical purposes but results must be interpreted within the full clinical investigation context. Specimens must be representative, as non-representative tissue types or depleted specimens may lead to erroneous results.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 47303-3
- 94736-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
2 slides
Container
Tissue block or 5 unstained, positively charged slides
Collection Instructions
Formalin fix and paraffin embed specimen. Protect from excessive heat. Use ARUP tissue transport kit #47808 for transport. Do not oven bake precut slides.
Storage Instructions
Room temperature or refrigerated; ship cooled in summer.
Causes for Rejection
Non-representative tissue type; depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |