Anaplastic Lymphoma Kinase 1 (ALK-1) by Immunohistochemistry

Also known as: ALK1 IHC

Clinical Use

Use

The Anaplastic Lymphoma Kinase 1 (ALK-1) by Immunohistochemistry test is intended for the clinical evaluation of tumors to determine the presence of the ALK protein expression. This test supports the diagnosis and characterization of certain malignancies, such as anaplastic large cell lymphoma, by detecting ALK protein overexpression or rearrangements, which can guide therapeutic decisions and interventions. ALK rearrangements are associated with a subset of cancers where targeted therapies may be effective.

Special Instructions

Not provided.

Limitations

The test is performed as a stain-only service and does not include interpretive analysis. It is intended for technical purposes, and the performance characteristics were determined by ARUP Laboratories. It is not FDA-cleared or approved. The test is done in a CLIA-certified laboratory for clinical purposes but results must be interpreted within the full clinical investigation context. Specimens must be representative, as non-representative tissue types or depleted specimens may lead to erroneous results.

Test Details

New York Approved

Methodology

Immunoassay (IHC)

Biomarkers

ALK

Protein

IHC

Expression • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Result Codes

47303-3 - ALK Ag Tiss Ql ImStn
94736-6 - Tissue block ID Spec

Result Turnaround Time

1-3 days

Specimen

Tissue (FFPE)

Volume

Not provided

Minimum Volume

2 slides

Container

Tissue block or 5 unstained, positively charged slides

Collection Instructions

Formalin fix and paraffin embed specimen. Protect from excessive heat. Use ARUP tissue transport kit #47808 for transport. Do not oven bake precut slides.