Aspergillus Antibodies by Complement Fixation and Immunodiffusion
Also known as: ASPER PRO
Use
The Aspergillus Antibodies by Complement Fixation and Immunodiffusion test aids in the diagnosis of allergic bronchopulmonary aspergillosis (ABPA) and aspergilloma. The test involves determining the presence of antibodies against Aspergillus species in the patient through complement fixation and immunodiffusion techniques. The presence of Aspergillus antibodies suggests either an active infection or exposure to the fungus, helping clinicians in diagnosing the condition and differentiating from other possible pulmonary issues.
Special Instructions
Parallel testing is preferred, and convalescent specimens should be received within 30 days from receipt of acute specimens. Mark specimens plainly as 'acute' or 'convalescent.'
Limitations
A titer of 1:8 or greater suggests Aspergillus infection or allergy, but cross-reactions with dimorphic fungi within the genus Aspergillus are not unusual. The presence of bands in immunodiffusion suggests recent or previous Aspergillus infection. However, no antibodies detected in immunodiffusion does not exclude Aspergillus infection, thereby affecting the sensitivity of the test. The test uses pooled mycelial-phase culture filtrates of multiple Aspergillus species, potentially impacting specificity.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 5052-6
- 5053-4
- 5053-4
- 5052-6
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.8 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to an ARUP standard transport tube. Parallel testing is preferred, and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as 'acute' or 'convalescent.'
Storage Instructions
Refrigerated
Causes for Rejection
Contaminated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |