Beta-2 Glycoprotein 1 Antibodies, IgG and IgM
Also known as: B2GPI PAN
Use
The test is an acceptable initial test when antiphospholipid syndrome (APS) is strongly suspected. It should be ordered with the Lupus Anticoagulant Reflex Panel and Cardiolipin Antibodies tests. It is also useful in estimating the risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus (SLE). The persistent presence of IgG and/or IgM beta 2 glycoprotein I (B2GPI) antibodies is a laboratory criterion for the diagnosis of APS. Persistence is defined as moderate or high levels detected in at least two specimens drawn at least 12 weeks apart.
Special Instructions
Order with Lupus Anticoagulant Reflex Panel and Cardiolipin Antibodies, IgG and IgM tests. Ensure proper sample collection and processing by maintaining appropriate test conditions.
Limitations
Results greater than 20 SGU (IgG) and/or SMU (IgM) are considered positive based on the cutoff values established for this test. However, international reference materials and consensus units for anti-B2GPI antibodies have not been established, meaning results can be variable between different commercial immunoassays and cannot be compared directly. Low positive and negative results should be interpreted in the context of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 44448-9
- 44449-7
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Draw blood in a serum separator tube. Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
Plasma or other body fluids. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |