Beta‑2‑Glycoprotein I Antibody (IgM)
Use
Beta‑2‑Glycoprotein 1 (also known as apolipoprotein H) acts as a cofactor in antiphospholipid antibody binding, and represents the critical antigen in antiphospholipid antibody syndrome (APS). Measurement of IgM antibodies against Beta‑2‑Glycoprotein I offers enhanced specificity compared to cardiolipin antibody, which may exhibit cross‑reactivity in patients with infections such as syphilis.
Special Instructions
Not provided.
Limitations
No limitations explicitly stated in available sources.
New York Approved
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 45030402
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1.0 mL
Minimum Volume
0.5 mL
Collection Instructions
Preferred: Sodium Citrate Plasma. Collect and label sample according to standard protocols. Fill the tube to the fill line. Gently invert tube 5 times immediately after draw. Do not shake. Centrifuge tube for 15 minutes at approximately 1500 x g within 60 minutes of collection. Using a plastic pipette, remove plasma without the buffy coat, place into plastic vial, centrifuge again and transfer platelet‑poor plasma (<10,000/mcL) into a new plastic vial. Label as “NaCit Plasma” and cap tightly. Transport at 2–8 °C and ship same day per shipping instructions.
Storage Instructions
Store specimen at 2 °C to 8 °C after collection and ship same day per packaging instructions.
Causes for Rejection
Improper labeling; samples not stored properly; samples older than stability limits; gross hemolysis; gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 5 days |
| Refrigerated | 14 days |
| Frozen | 30 days |