Beta-2 Glycoprotein 1 Antibodies, IgG, IgM and IgA
Also known as: B2GPI PAN3
Use
The persistent presence of IgG and/or IgM beta 2 glycoprotein I (B2GPI) antibodies is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG or IgM B2GPI antibodies detected in two or more specimens drawn at least 12 weeks apart. Results greater than 20 SGU (IgG) or SMU (IgM) are considered positive. Strong clinical correlation is recommended for a diagnosis of APS, and low positive levels should be interpreted in light of APS-specific clinical manifestations and other criteria phospholipid antibody tests.
Special Instructions
Strong clinical correlation with APS-specific symptoms is recommended. Results cannot be compared with other commercial immunoassays due to lack of international reference materials for anti-B2GPI antibodies.
Limitations
International reference materials and consensus units for anti-B2GPI antibodies have not been established. Results can be variable between different commercial immunoassays and cannot be directly compared.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 21108-6
- 44448-9
- 44449-7
- 44448-9
- 44449-7
- 21108-6
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Serum separator tube
Collection Instructions
Transfer to an ARUP Standard Transport Tube after collection.
Storage Instructions
Refrigerated
Causes for Rejection
Plasma or other body fluids, contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |