Coccidioides Antibodies by Complement Fixation
Also known as: COCCI
Use
This test is used to monitor coccidioidal antibody titer in serum in response to treatment. A titer of 1:2 or greater suggests past or current infection. It is also used to follow therapy, as anticoccidioidal CF antibody titers in excess of 1:16 may indicate disseminated infection. Antibody presence in CSF is considered diagnostic for coccidioidal meningitis, although 10 percent of patients with coccidioidal meningitis will not have antibody in CSF.
Special Instructions
Mark specimens plainly as "acute" or "convalescent." Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens.
Limitations
Greater than 30 percent of cases with chronic residual pulmonary disease have negative complement fixation (CF) tests. Titers of less than 1:32 (even as low as 1:2) may indicate past infection or self-limited disease. Not all patients with coccidioidal meningitis will have antibodies in CSF.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Other)
Biomarkers
LOINC Codes
- 33380-7
Result Turnaround Time
2-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.6 mL
Container
ARUP standard transport tube
Collection Instructions
Separate from cells ASAP or within 2 hours of collection.
Causes for Rejection
Other body fluids. Contaminated, hemolyzed, icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |