Use

Immunohistochemical staining for H3K27me3 (histone H3 lysine 27 trimethylation) is used as a technical stain-and-return service, typically to assist in diagnostic pathology. It is often helpful in evaluating tumor types such as malignant peripheral nerve sheath tumors or other neoplasms where loss or retention of H3K27me3 expression provides diagnostic insight. This test is performed laboratory‑developed test (LDT) and cannot be used for definitive mutation analysis, but serves as an adjunct immunohistochemical marker.