MYC (8q24) Gene Rearrangement by FISH
Also known as: MYC FISH
Use
This test facilitates the diagnosis of Burkitt's lymphoma (BL) and B-cell lymphoma with features intermediate between BL and diffuse large B-cell lymphoma (DLBCL). It detects all MYC rearrangements, including translocations t(8;14), t(2;8), and t(8;22). MYC rearrangement is seen in a variety of B-cell lymphomas, including 'double hit' or 'triple hit' lymphomas, and results should be correlated with clinical, morphologic, and immunophenotypic data.
Special Instructions
The specimen provided must be accompanied by a surgical pathology report. If multiple specimens (blocks or slides) are submitted to ARUP, an order comment indicating the ARUP pathologist should choose the appropriate specimen for testing or individual orders for each sample must accompany them. A Pathologist Block Selection Fee (ARUP test code 3002076) will be added if the pathologist selection option is utilized.
Limitations
This test is expected to detect 100 percent of MYC rearrangements in patients with MYC-rearranged lymphomas, except for rare instances of cryptic rearrangements. The use of this assay on decalcified tissues has not been validated, so results should be interpreted with caution. It has not been cleared or approved by the U.S. Food and Drug Administration and was developed by ARUP Laboratories.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 81304-8
- 78236-7
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Tissue block or 5 unstained slides
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin-embed specimen. Use ARUP supply #47808 for transportation.
Storage Instructions
Protect paraffin block from excessive heat. Transport tissue block or 5 unstained slides in a tissue transport kit. Use a cooled container during summer months.
Causes for Rejection
Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |