High-Grade B-Cell Lymphoma, FISH

Clinical Use

Use

Diagnostic test for non-Hodgkin’s lymphoma (NHL). Detects primary genetic changes associated with various types of NHL, including follicular lymphoma (FL), Burkitt's lymphoma (BL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), and those with BCL6 rearrangement.

Special Instructions

Not provided.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probes included in this profile will not be detected. Chromosome analysis should be considered to identify clonal alterations not targeted by the FISH probes ordered.

Test Details

Methodology

Chromosomal / Cytogenetics (FISH)

Biomarkers

No genes

Gene

FISH

Mutation • Categorical (e.g., Positive / Negative / Indeterminate)

No genes

Gene

FISH

Mutation • Categorical (e.g., Positive / Negative / Indeterminate)

No genes

Gene

FISH

Mutation • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Result Codes

62361-1 - Cells counted
62360-3 - Cells analyzed
48674-6 - Genetic diseases Bld/T FISH
50398-7 - Narrative diagnostic report-Imp
31208-2 - Specimen source

Result Turnaround Time

3-5 days

Specimen

Whole Blood

Volume

5 mL whole blood (pediatric)

Minimum Volume

1 mL whole blood (pediatric)

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal)

Collection Instructions

Utilize sterile technique and Labcorp transport kits when possible.

Storage Instructions

Transport to the testing laboratory at room temperature, use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.