High-Grade B-Cell Lymphoma, FISH
Use
Diagnostic test for non-Hodgkin’s lymphoma (NHL). Detects primary genetic changes associated with various types of NHL, including follicular lymphoma (FL), Burkitt's lymphoma (BL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), and those with BCL6 rearrangement.
Special Instructions
Indicate the pertinent clinical diagnosis and previous cytogenetic studies on the test request form. Note: This test number is used for tracking FISH specimens to the laboratory.
Limitations
Molecular mutations or chromosomal alterations not targeted by the probes included in this profile will not be detected. Chromosome analysis should be considered to identify clonal alterations not targeted by the FISH probes ordered.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 62361-1
- 62360-3
- 48674-6
- 50398-7
- 31208-2
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL whole blood (pediatric)
Minimum Volume
1 mL whole blood (pediatric)
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal)
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible.
Storage Instructions
Transport to the testing laboratory at room temperature, use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.
Causes for Rejection
Broken Vacutainer®; broken or stained slides; decalcified bone core; frozen specimen; quantity not sufficient for analysis