Phosphatidylserine Antibodies, IgG and IgM
Also known as: PHOSSER GM
Use
IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein antibodies. Isolated presence of IgM or IgG antibodies to aPS may have questionable clinical significance for APS and/or SLE.
Special Instructions
Preferred second-line test when seronegative antiphospholipid syndrome (APS) is strongly suspected. Order incrementally or concurrently with other noncriteria antiphospholipid antibody tests. If results are positive, repeat testing with two or more specimens drawn at least 12 weeks apart to demonstrate persistence of antibodies.
Limitations
Results should not be used alone for diagnosis and must be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests. The isolated presence of IgG or IgM antibodies may have questionable significance. Interpretation requires correlation with clinical findings and other lab results.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 32032-5
- 32033-3
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated
Causes for Rejection
Heat-inactivated, contaminated, grossly icteric, grossly hemolyzed, or severely lipemic specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 month |