Placental Alkaline Phosphatase (PLAP) by Immunohistochemistry

Also known as: PLAP IHC

Clinical Use

Use

Placental Alkaline Phosphatase (PLAP) by Immunohistochemistry is used for the detection and localization of PLAP expression in tissue sections. PLAP is an enzyme that is present in high amounts in the placenta but is also found in certain tumors, making it a valuable marker in cancer diagnosis, especially germ cell tumors. The test is useful in identifying and characterizing neoplastic cells, providing important diagnostic and prognostic information.

Special Instructions

Not provided.

Limitations

This test is performed as a stain and return (technical) service only. The test's sensitivity and specificity may vary depending on the laboratory procedures and the pathological condition of the tissue. It is not intended for use in detecting PLAP in the bloodstream or other body fluids. Immunohistochemical analysis may be influenced by tissue fixation, handling, and processing techniques, which can affect the expression levels of PLAP.

Test Details

New York Approved

Methodology

Immunoassay (IHC)

Biomarkers

Placental Alkaline Phosphatase

Protein

IHC

Expression • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Result Codes

94736-6 - Tissue block ID Spec

Result Turnaround Time

1-3 days

Specimen

Tissue (FFPE)

Volume

Not provided

Minimum Volume

Not provided

Container

Tissue transport kit (ARUP supply #47808)

Collection Instructions

Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides.