Placental Alkaline Phosphatase (PLAP) by Immunohistochemistry
Also known as: PLAP IHC
Use
Placental Alkaline Phosphatase (PLAP) by Immunohistochemistry is used for the detection and localization of PLAP expression in tissue sections. PLAP is an enzyme that is present in high amounts in the placenta but is also found in certain tumors, making it a valuable marker in cancer diagnosis, especially germ cell tumors. The test is useful in identifying and characterizing neoplastic cells, providing important diagnostic and prognostic information.
Special Instructions
IMMUNOHISTOCHEMISTRY ORDERING AND SUBMISSION DETAILS: Submit electronic request. If you do not have electronic ordering capability, use an ARUP Immunohistochemistry Stain Form (#32978) with an ARUP client number. Protect paraffin block and/or slides from excessive heat. Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides in a tissue transport kit.
Limitations
This test is performed as a stain and return (technical) service only. The test's sensitivity and specificity may vary depending on the laboratory procedures and the pathological condition of the tissue. It is not intended for use in detecting PLAP in the bloodstream or other body fluids. Immunohistochemical analysis may be influenced by tissue fixation, handling, and processing techniques, which can affect the expression levels of PLAP.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
LOINC Codes
- 94736-6
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Tissue transport kit (ARUP supply #47808)
Collection Instructions
Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock). Transport tissue block or 5 unstained (3- to 5-micron thick sections), positively charged slides.
Storage Instructions
Room temperature or refrigerated. Ship in cooled container during summer months.
Causes for Rejection
Specimens submitted with non-representative tissue type. Depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |