Signal Recognition Particle (SRP) Antibody
Also known as: SRP
Use
The Signal Recognition Particle (SRP) Antibody test is used to detect autoantibodies against the SRP complex, which are associated with idiopathic inflammatory myopathies, particularly polymyositis. A positive result indicates the presence of these autoantibodies, which can aid in the diagnosis of certain autoimmune conditions and help differentiate between different types of myopathy. Autoantibodies against SRP are relatively rare but when present, they can be indicative of a severe form of polymyositis that often necessitates aggressive treatment.
Special Instructions
Testing is performed by a non-ARUP Laboratory. It is essential to provide separate specimens if multiple tests are ordered concurrently. Proper specimen handling and preparation are required to ensure test accuracy. Specimen collection includes the use of a plain red or serum separator tube. Transfer of 1 mL serum to an ARUP standard transport tube is needed, with a minimum collection volume of 0.3 mL.
Limitations
This test has not been cleared or approved by the Food and Drug Administration. Results should be interpreted in the context of a comprehensive clinical evaluation. False positives and negatives can occur, and the presence of SRP antibodies may not be exclusively linked to any specific disease. The test does not provide information on disease activity or severity and should be interpreted alongside other clinical and laboratory findings to make a diagnosis.
New York Approved
Methodology
Immunoassay (RIA)
Biomarkers
LOINC Codes
- 33921-8
Result Turnaround Time
16-24 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP standard transport tube
Collection Instructions
Transfer 1 mL serum to an ARUP standard transport tube. A plain red or serum separator tube should be used for collection.
Storage Instructions
Refrigerated is preferred, also acceptable when frozen.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 2 months |